SEKANINOVÁ Jana Brno University of Technology, CEITEC - Central European Institute of Technology

Study of Preparation and Structure of Polycaprolactone and Biocomposite Nanofibers from Hydroxyapatite/Polycaprolactone

Co-authors CIHLÁŘ Jaroslav

The preparation (by centrifugal jet spinning method) and structure of polycaprolactone (PCL) nanofibers and composite nanofibers hydroxyapatite (HAp)/PCL were studied. First, solutions of PCL in chloroform with concentration 5 to 9 wt.% were prepared, then dispersions HAp in PCL solutions with concentration from 0.1 to 0.5 wt.% of HAp in 9 wt.% were prepared. HAp was synthesized by sol-gel the method at room temperature and pressure and pH 12. The nanofibers were spun at the rate from 6 000 to 11 000 rpm. Two sizes of collector were used. The morphology and thickness of the nanofibers in dependence on the properties of solutions or dispersions and conditions of spinning were studied. Finally, bioactivity of nanofibers using simulated body fluid (SBF) solution was also tested. The results could be used for preparation of scaffolds in bone tissue engineering.