CÍGLER Petr Institute of Organic Chemistry and Biochemistry of the ASCR, v.v.i.

Nanodiamonds as Fluorescent Probes with Unlimited Photostability

In recent years, diamond nanoparticles have received a great deal of attention due to their unique photophysical and biological properties. They are used as promising near-infrared luminescent probes and sensors in biomedical research, possessing unique properties such as absolute photostability and high biocompatibility. A complex route towards bioapplicable fluorescent nanodiamonds (NDs) will be presented. It includes boosting of ND fluorescence [1], shaping the ND particles to become pseudospherical [2,3], separation of particles by size and also creation of antifouling polymeric coating on fluorescent NDs [4]. These probes can be bioorthogonaly modified with various (bio)molecules using click chemistry and targeted to cancer cells with unprecedent effectivity [5]. New types of plasmonic particles bearing a thin gold shell on a ND core and their use in cancer thermoablation will be also presented [6]. LITERATURE: [1] J. Havlik, V. Petrakova, et al., Nanoscale, 2013, 5, 3208–3211. [2] I. Rehor et al., Small, 2014, 10(6), 1106–1115. [3] Z. Chu et al., Sci Reports, 2014, 4 : 4495. [4] I. Rehor et al., ChemPlusChem, 2013, 79(1), 21-24. [5] J. Slegerova et al., Nanoscale, 2014, DOI: 10.1039/c4nr02776k. [6] I. Rehor, K. L. Lee et al., Adv Healthcare Mater, 2014, DOI: 10.1002/adhm.201400421.