RUDAKOVSKAYA Polina National University of Science and Technology "MISIS"

Synthesis and Characterization of PEG-Silane Functionalized Iron Oxide Nanoparticle as MRI Contrast Agent

Co-authors METELKINA Olga, BELOGLAZKINA Elena, ZYK Nykolay, SAVCHENKO Alexander, SCHETININ Igor, SALIHOV Sergey, ABAKUMOV Maxim, KLYACHKO Nataliya, GOLOVIN Yuriy, KABANOV Alexander, MAJOUGA Alexander
Collaboration: Lomonosov Moscow State University, Moscow, Russian Federation; Russian National Research Medical University, Moscow, Russian Federation; University of North Carolina at Chapel Hill, North Carolina, USA

Magnetic nanoparticles, especially iron oxide nanoparticles, have shown a large interest in biomedical imaging (such as contrast agents for Magnetic Resonance Imaging (MRI)) thanks to their chemical and biological properties. Nowadays, many studies highlight the multimodal imaging and the last advances in theranostic which combines diagnosis and therapy. .Herein we report the synthesis, functionalization process and characterization of superparamagnetic and ferrimagnetic iron oxide nanoparticles with different shape and size. Special attention in this paper devoted to covalent stabilization of magnetite nanoparticles by polymer, such as silane-polyethylene glycol (Peg-silane). The major advantage of modified by polymer magnetic nanoparticles is low toxicity and possibility for post functionalization. Iron oxide nanoparticles with different morphology (spheres, cubes, rods) were obtained by coprecipitation or redox methods. Nanoparticle size, shape and magnetic properties analysis was then used to determine the properties of iron oxide nanoparticle. Iron oxide suspensions were reacted with aqueous PEG-silane to perform phase transfer functionalization. Surface of iron oxide nanoparticles were modified by excess amount of PEG-silane. The PEG-silane magnetic nanoparticles were dispersed in aqueous solution and analyzed by TEM, TGA, DLS, NTA methods, and their magnetic properties were determined. Prepared nanoparticles have great interest and potential for use in biomedical imaging.