PEKÁRKOVÁ Jana Brno University of Technology

Synthesis of CdTe/ZnS Core/Shell Quantum Dots and Their In Vitro Toxicity Assessment

Co-authors FOHLEROVÁ Zdenka, Drbohlavová Jana, PEKÁREK Jan, MAJZLÍKOVÁ Petra, PRÁŠEK Jan, HUBÁLEK Jaromír

Quantum dots (QDs) are well known semiconductor nanocrystals that have been extensively investigated as visible drug carriers or imaging agents due to their unique optical properties. Nevertheless, potential toxicity is still one of the major issues that limit the advances of QDs into clinical studies. In this paper, water soluble CdTe core a CdTe/ZnS core/shell QDs stabilized with different ligands (3-mercaptoacetic acid, thioglycolic acid, glutathione and mercaptosuccinic acid) were prepared by a simple method using Na2TeO3 and CdCl2. For comparison, ZnSe and ZnSe/ZnS QDs were also prepared. QDs cytotoxicity on Human Embryonic Kidney cells (HEK 293) was performed using MTT (3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide) viability assay. Single core CdTe QDs were found to have severe toxic effects on cells due to the absence of a zinc sulfide shell, which normally decreases the toxicity of QDs.