MAJOUGA Alexander National University of Science and Technology MISIS

Nanohybrid Core-Shell Magnetic Materials for Biomedical Application

Co-authors Savchenko A.G., M. Sokolsky-Papkov, Beloglazkina E.K., Zyk N.V., Golovin U.I., Klyachko N.L., Kabanov A.V.

Gold-coated magnetic nanoparticles are a class of nanoparticles that have attracted much attention because of their advantageous characteristics, such as their inertness, non-toxicity, super magneticity, ease of detection in the human body, a magnetic core that is protected against oxidation, their facilitated bio-conjugating ability, catalytic surface, and their potential for a variety of biological applications. Gold-coated nanoparticles have great biocompatibility with the human body with the ability to interact with biomolecules such as polypeptides, DNA, and polysaccharides. Herein we report a synthetic procedure for the preparation of water-soluble Fe3O4@Au core-shell nanoparticles, simple protocol for their purification by exclusion chromatography and methof for functionalization of gold surface with a number of sulfur-containing ligands. We describe a distinct effect of non-heating superlow-frequency magnetic fields on the kinetics of chemical reactions catalyzed by the enzymes -chymotrypsin (ChT) immobilized on core-shell nanoparticles.