ERBEN Jakub Technical University of Liberec, Department of Nonwovens

3D Micro-nano Fibrous Scaffold prepared by Meltblown in Combination with Electrospinning for the Bone Tissue Engeneering

Co-authors JENČOVÁ Věra, PILAŘOVÁ Kateřina, BLAŽKOVÁ Lenka, KOŠŤÁKOVÁ Eva, SANETRNÍK Filip, CHVOJKA Jiří, MIKEŠ Petr, LUKÁŠ David

This study describes the development of a novel composite material for tissue engineering consisting of microfibers produced by meltblown technology ensuring optimal three dimensional porous structure and sufficient mechanical properties, electrospun nanofibers for good cell adhesion and particles of hydroxyapatite enhancing increasing the biological activity and mineralization of regenerated bone tissues. The production is continuous and all technologies are composed into one step. This newly formed composite set the excellent biodegradable properties tested by enzymatically catalyzed hydrolysis. The preliminary in-vitro tests showed the high potential of developed composite materials in TE - good porosity of the tested materials allows osteoblasts to proliferate into the sample inner structure with the significant contribution of nanofibers content to the cell proliferation rate.

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