Mgr. Petr CÍGLER, Ph.D.

Institute of Organic Chemistry and Biochemistry of the Academy of Sciences of the Czech Republic, v.v.i., Prague, Czech Republic, EU

 

Position: Head of Synthetic Nanochemistry Group Institute of Organic Chemistry and Biochemistry Academy of Sciences of the Czech Republic, v.v.i., Prague, Czech Republic, EU

Specialization: nanoparticles for use in medicine-preparation and functionalization, molecular design, organic and inorganic synthesis

 

At the NANOCON 2014 conference Petr Cígler will present the invited lecture in the Session C – Bionanotechnology, Nanomaterials in Medicine.

 

Education and Career Accomplishments:
Petr Cígler (35) is a chemist with broad experience in chemical synthesis and analysis of organic molecules, biomolecules and nanoparticles. He received his Ph.D. at the Institute of Chemical Technology Prague, Czech Republic, EU, in 2008. Simultaneously with his Ph.D. study he worked as a research associate dealing with design and synthesis of inhibitors of HIV protease and serine racemase at the Institute of Organic Chemistry and Biochemistry, Academy of Sciences Czech Republic (IOCB) (from 2005 to 2008). Thereafter he joined The Scripps Research Institute (TSRI) in the U.S.A. At this nonprofit research institution focused on the biosciences and its application in medicine he worked on design and preparation of functional virus-like particles and nanoparticles self-assembly, molecular recognition, and selective chemical functionalization (from 2008 to 2009). Next three years (2009-2012) P. Cígler worked as a researcher at IOCB and from the year 2013 he is a head of the Synthetic Nanochemistry Group.

 

Recent Awards:

  • 2013 Premium Otto Wichterle (prize for outstanding researchers of Academy of Sciences of the CR younger 35 years)
  • 2012 Scopus Awards (1st place) [the prize for a best scientific work published by a Czech scientist younger 35 years; the awarded work: Cigler et al. (2010) Nat. Mater., 9, 918.]
  • 2012 Prize of The Learned Society of the Czech Republic for pedagogues (for mentoring of Chemistry Olympiad and for continuous work with talented high school students)
  • 2011 Alfred Bader Prize for Bioorganic and Bioinorganic Chemistry (an award for a top Czech chemist younger 35 years working in bioorganic and/or bioinorganic chemistry)

 

Research interests:
Research interest of Petr Cígler is focused on multidisciplinary projects in medicinal chemistry, molecular and nanoparticle design, new fluorescence probes, surface chemistry of nanoparticles, functionalization of proteins and DNA, enzyme inhibition and boron clusters. The group led by Dr. Cígler studies new types of nanoparticles for use in therapeutics, imaging and diagnostics of diseases. Studied nanomaterials are based either on bioorganic or inorganic cores and includes viral-like particles, fluorescent nanodiamonds and plasmonic systems. The group is focused on biocompatibilization of nanoparticles, their targeting to cells and on non-invasive, remote control of nanoparticles’ action in cells by external stimuli.

 

Bibliography:
Total number of citations: 570 (>500 without self-citations), H factor: 11, total number of peer reviewed papers: 35.

Selected recent articles:

  • Rehor I., Slegerova J., Kucka J., Proks V., Petrakova V., Adam M.-P., Treussart F., Turner S., Bals S., Sacha P., Ledvina M., Wen A. M., Steinmetz N. F., and Cigler P. (2014). Fluorescent Nanodiamonds Embedded in Biocompatible Translucent Shells. Small, DOI: 10.1002/smll.201302336
  • Havlik, J., Petrakova, V., Rehor, I., Petrak, V., Gulka, M., Stursa, J., Kucka, J., Ralis, J., Rendler, T., Lee, S.-Y., Reuter, R., Wrachtrup, J., Ledvina, M., Nesladek, M., & Cigler P. (2013). Boosting Nanodiamond Fluorescence: Towards Development of Brighter Probes. Nanoscale,5, 3208-3211.
  • Brynda, J., Mader, P., Šícha, V., Fábry, M., Poncová, K., Bakardiev, M., Grüner, B., Cígler, P. and Řezáčová, P. (2013). Carborane-Based Carbonic Anhydrase Inhibitors. Angew. Chem. Int. Ed., 52(51), 13760-13763.
  • Rehor I., Mackova H., Filippov S. K., Kucka J., Proks V., Slegerova J., Turner S., Vandeloo G. V., Ledvina M., Hruby M., Cigler P. (2013). Fluorescent nanodiamonds with bioorthogonally reactive protein-resistant polymeric coatings, ChemPlusChem, 79(1), 21-24.
  • Rak J., Dejlová B., Lampová H., Kaplánek R., Matějíček P., Cígler P., Král V. (2013). On the Solubility and Lipophilicity of Metallacarborane Pharmacophores, Mol. Pharmaceutics, 10, 1751−1759.
  • Petrakova, V., Taylor, A., Kratochvilova, I., Fendrych, F., Vacik, J., Kucka, J., Stursa, J., Cigler, P., Ledvina, M., Fiserova, A., Kneppo, P. & Nesladek, M. (2012). Luminescence of Nanodiamond Driven by Atomic Functionalization: Towards Novel Detection Principles. Adv. Funct. Mater.,22, 812–819.
  • Schimer, J., Cígler, P., Veselý, J., Grantz Šašková, K., Lepšík, M., Brynda, J., Řezáčová, P., Kožíšek, M., Císařová, I., Oberwinkler, H., Kraeusslich, H.-G. & Konvalinka, J. (2012). Structure-aided design of novel inhibitors of HIV protease based on a benzodiazepine scaffold. J. Med. Chem., 55(22), 10130–10135.

 

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