ABKHALIMOV Evgeny A.N. Frumkin Institute of Physical Chemistry and Electrochemistry of RAS

Spoluautoři ISAKOVA Alexandra, IVANOVA Marina, IVANOVA Valeriya, GALUSHKO Tatyana, AFONINA Ludmila, SPITSYN Boris
Spolupracující instituce: D.I. Ivanovsky Institute of Virology of Ministry of Health of the Russian Federation, Moscow, Russian Federation

The main reason of not gained interest of researchers to the detonation-synthetized nanodiamond (DND) particles is a simplest carbon nanomaterial. The surface of its particles hasn’t oxide phase and is multifunctional that allows to carry out the directed chemical modifying of its surface. Commercial DND has essential features which limit its application in nanobiotechnology. In this work, the directed chemical modifying of a surface of commercial DND produced by Sinta (Minsk, Republic of Belarus) is carried out. The DNDs with the amine-, chlorine-group, and partially graphitized surface were synthetized. Its physical and chemical properties, including dzetta-potential are investigated. In wide pH-range the DNDs with oxidized surface have exhibited high sedimentation stability in aqueous solutions. For the purpose to use the chemical-modified DMD in biotechnological or medical applications, the assessment of its ability to sorb viruses has been carried out. The HA titers of influenza viruses decreased in 8 till 500 times after contact with sorbents. The toxic properties of the chemical-modified DMD on cotton rats have been estimated. The Assessment of embryo toxicity, teratogenicity and mutagenicity has been carried out on Zebrafish (Danio rerio). ACKNOWLEDGEMENTS: This work was supported by a grant of MK-3937.2013.3 ; the Cooperative Agreement N 1U51│P000527-01, CDC&P, USA; RFBR 14-03-31817.